Linked Life Data

14961043

Source:http://linkedlifedata.com/resource/pubmed/id/14961043

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-4-22
pubmed:abstractText
Population blood pressure variation is most likely due to multiple genes. This is likely the reason why monogenic testing with the angiotensinogen (AGT) gene polymorphisms on chromosome 1 (1q42-43), especially M235T, has met with negative results, especially in those of African descent. The RH blood group system, also on chromosome 1 (1 p36.2-34), has likewise been associated with blood pressure variation in African-Americans and with the rise in blood pressure with age in whites. Using a random sample of the population, we investigated the combined effects of single and combined variation of the AGTN M235T and RH genotypes on blood pressure, lipids, and lipoprotein concentrations in Afro-Caribbeans aged 18-60 years from the island nation of Dominica. In monogenic analysis, AGT M235T was not associated with blood pressure. However, it was associated with HDL (MM 42+/-23, MT 44+/-12, TT 52+/-14 (P=0.002)). RH genotype was significantly associated with systolic blood pressure (P=0.006) and Apo-A (P=0.003). These effects remained after adjustment for age, gender, weight, and BMI. In the polygenetic analysis, AGT M235T and RH were significantly associated with systolic blood pressure (P=0.037; interaction effects, P=0.068). The association of the AGT M235T with blood pressure across RH blood group haplotypes was then tested. Of the five RH haplotypes available for analysis, the AGT M235T was significantly associated with blood pressure within the "D" haplotype (P=0.01). The RH blood group and gender were significantly associated with systolic blood pressure and Apo-A levels (P=0.005 and 0.012, respectively). All interactions were independent of age and weight. In conclusion, we demonstrate a significant association of AGT M235T with blood pressure and cholesterol metabolism in an Afro-Caribbean population in the "genetic context" of the RH blood group system. Further investigation of these interactions may help understand the effects of genetic factors on cardiovascular risk in African-derived and other populations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0950-9240
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:14961043-Adult, pubmed-meshheading:14961043-African Continental Ancestry Group, pubmed-meshheading:14961043-Angiotensinogen, pubmed-meshheading:14961043-Blood Pressure, pubmed-meshheading:14961043-Cardiovascular Diseases, pubmed-meshheading:14961043-Caribbean Region, pubmed-meshheading:14961043-Demography, pubmed-meshheading:14961043-Female, pubmed-meshheading:14961043-Genotype, pubmed-meshheading:14961043-Haplotypes, pubmed-meshheading:14961043-Humans, pubmed-meshheading:14961043-Lipids, pubmed-meshheading:14961043-Male, pubmed-meshheading:14961043-Methionine, pubmed-meshheading:14961043-Middle Aged, pubmed-meshheading:14961043-Polymorphism, Genetic, pubmed-meshheading:14961043-Rh-Hr Blood-Group System, pubmed-meshheading:14961043-Risk Factors, pubmed-meshheading:14961043-Threonine
pubmed:year
2004
pubmed:articleTitle
AGT and RH blood group polymorphisms affect blood pressure and lipids in Afro-Caribbeans.
pubmed:affiliation
Department of Psychiatry, UC San Diego, La Jolla, CA, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't