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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1992-9-4
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pubmed:abstractText |
The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was related to the mAb's ability to inhibit virus spread from cell to cell and to restrict rabies virus RNA transcription. Since treatment of rabies virus-infected cells with virus-neutralizing mAbs results in an endocytosis of the antibody, we hypothesize that an antibody may exert its inhibitory activity even after uptake by the cell. Post-exposure treatment of rats with a mAb that inhibited both virus spread and virus RNA transcription in vitro resulted in viral clearance from the central nervous system and protected the animals against a lethal rabies virus infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-1376367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-1658936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-1695255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-1709692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-2000406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-2016778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-2335829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-2470920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-2760222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-279009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-3084289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-3672933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-3897571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-4266465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-4960454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6094202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6190924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6202788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6526138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6772444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6975354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-6988546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1496020-7334080
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7252-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1496020-Actins,
pubmed-meshheading:1496020-Animals,
pubmed-meshheading:1496020-Antibodies, Monoclonal,
pubmed-meshheading:1496020-Antibodies, Viral,
pubmed-meshheading:1496020-Base Sequence,
pubmed-meshheading:1496020-Blotting, Northern,
pubmed-meshheading:1496020-Blotting, Southern,
pubmed-meshheading:1496020-Brain,
pubmed-meshheading:1496020-Capsid,
pubmed-meshheading:1496020-Cell Line,
pubmed-meshheading:1496020-Female,
pubmed-meshheading:1496020-Mice,
pubmed-meshheading:1496020-Mice, Inbred ICR,
pubmed-meshheading:1496020-Molecular Sequence Data,
pubmed-meshheading:1496020-Neuroblastoma,
pubmed-meshheading:1496020-Neutralization Tests,
pubmed-meshheading:1496020-Oligonucleotide Probes,
pubmed-meshheading:1496020-Polymerase Chain Reaction,
pubmed-meshheading:1496020-RNA, Messenger,
pubmed-meshheading:1496020-RNA, Viral,
pubmed-meshheading:1496020-Rabies,
pubmed-meshheading:1496020-Rabies virus,
pubmed-meshheading:1496020-Rats,
pubmed-meshheading:1496020-Rats, Inbred Lew,
pubmed-meshheading:1496020-Transcription, Genetic,
pubmed-meshheading:1496020-Viral Core Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.
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pubmed:affiliation |
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19109.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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