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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1992-9-4
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pubmed:abstractText |
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-1347469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-162962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-1664410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-1673574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-1685485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-2003334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-2187341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-2300582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-2309780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-2806116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-2889817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-3000867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-3321989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-36985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-4435358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-5565073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-6329026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-6338343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-7117820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495987-863229
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6968-72
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1495987-Alleles,
pubmed-meshheading:1495987-Animals,
pubmed-meshheading:1495987-Blotting, Southern,
pubmed-meshheading:1495987-Chromosome Deletion,
pubmed-meshheading:1495987-Crosses, Genetic,
pubmed-meshheading:1495987-DNA,
pubmed-meshheading:1495987-Eye Color,
pubmed-meshheading:1495987-Female,
pubmed-meshheading:1495987-Genes, Recessive,
pubmed-meshheading:1495987-Genotype,
pubmed-meshheading:1495987-Male,
pubmed-meshheading:1495987-Mice,
pubmed-meshheading:1495987-Mice, Inbred Strains,
pubmed-meshheading:1495987-Mice, Mutant Strains,
pubmed-meshheading:1495987-Mutation
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pubmed:year |
1992
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pubmed:articleTitle |
Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
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pubmed:affiliation |
Medical Research Council Radiobiology Unit, Didcot, Oxon, England.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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