| pubmed-article:1495975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1495975 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:1495975 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:1495975 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:1495975 | pubmed:dateCreated | 1992-9-4 | lld:pubmed |
| pubmed-article:1495975 | pubmed:abstractText | We have developed a method of specifically modifying the mammalian genome in vivo. This procedure comprises heritable tissue-specific and site-specific DNA recombination as a function of recombinase expression in transgenic mice. Transgenes encoding the bacteriophage P1 Cre recombinase and the loxP-flanked beta-galactosidase gene were used to generate transgenic mice. Genomic DNA from doubly transgenic mice exhibited tissue-specific DNA recombination as a result of Cre expression. Further characterization revealed that this process was highly efficient at distinct chromosomal integration sites. These studies also imply that Cre-mediated recombination provides a heritable marker for mitoses following the loss of Cre expression. This transgene-recombination system permits unique approaches to in vivo studies of gene function within experimentally defined spatial and temporal boundaries. | lld:pubmed |
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| pubmed-article:1495975 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1495975 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1495975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1495975 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1495975 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1495975 | pubmed:author | pubmed-author:RaevuoriMM | lld:pubmed |
| pubmed-article:1495975 | pubmed:author | pubmed-author:ChuiDD | lld:pubmed |
| pubmed-article:1495975 | pubmed:author | pubmed-author:OrbanP CPC | lld:pubmed |
| pubmed-article:1495975 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1495975 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1495975 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1495975 | pubmed:geneSymbol | loxP | lld:pubmed |
| pubmed-article:1495975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1495975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1495975 | pubmed:pagination | 6861-5 | lld:pubmed |
| pubmed-article:1495975 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1495975 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1495975 | pubmed:articleTitle | Tissue- and site-specific DNA recombination in transgenic mice. | lld:pubmed |
| pubmed-article:1495975 | pubmed:affiliation | Biomedical Research Centre, University of British Columbia, Vancouver, Canada. | lld:pubmed |
| pubmed-article:1495975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1495975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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