Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1992-9-4
pubmed:databankReference
pubmed:abstractText
Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination, they have widely spread in natural populations of the house mouse (10-40% in frequency) because of the meiotic drive advantage. We sequenced 14 Tcp-1 (t-complex polypeptide 1) genes from four t haplotypes, nine wild mice, and a rat as a reference. From a comparison of intron sequences of 610 base pairs, we dated the origin of t haplotypes to 2.9 +/- 0.7 million years ago, which predates the splitting of Mus musculus subspecies (approximately 1 million years ago). However, the Tcp-1 intron sequences of t haplotypes from different M. musculus subspecies from various parts of the world show no divergence, indicating the recent introgression (no earlier than 0.8 million years ago) of a single ancestral type. Nucleotide changes in coding regions are also consistent with this conclusion. Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-1543916, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-1794045, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-1901944, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-1937024, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-1972327, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-2016041, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-2030731, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-2323558, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-2717616, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-2897062, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-2897063, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3089698, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3416645, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3447015, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3731841, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3731842, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3753900, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3909941, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-3943128, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-409339, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-455464, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-6201441, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-6315529, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-6375655, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-6722884, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-7161808, http://linkedlifedata.com/resource/pubmed/commentcorrection/1495973-7433120
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
6851-5
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus.
pubmed:affiliation
Department of Microbial Genetics, Osaka University, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't