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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1992-9-8
|
| pubmed:abstractText |
Laryngeal chondrosarcomas are uncommon, and those that contain a distinct, nonchondroid, high-grade spindle cell sarcoma (the so-called "dedifferentiated" chondrosarcoma or chondrosarcoma with additional malignant mesenchymal component [CAMMC]) are extremely rare. Laryngeal CAMMC merit special attention, as CAMMC in other sites portends a poor prognosis. Eleven patients with laryngeal chondrosarcomas are reported on; 2 of these patients had CAMMC. On follow-up, 3 of the 11 patients had recurrences. The first had recurrence 4 and 11 years after tumor enucleation; that patient died disease free 2 years after salvage total laryngectomy. The second had recurrence 2 years after partial laryngectomy and was lost to follow-up after salvage total laryngectomy. The last patient recurred 13 years after partial laryngectomy and underwent salvage total laryngectomy; that patient was one of the two who developed CAMMC, and he also developed stomal recurrence of the "dedifferentiated" component 3 years after total laryngectomy. The other 8 patients are disease free after partial laryngectomy (6) or total laryngectomy (2) 10 months to 12 years later (mean: 51 months). This includes the 1 other patient with CAMMC, who is disease free 60 months after total laryngectomy. Laryngeal CAMMC has been shown, in at least one of the two patients, to be associated with a poor outcome. Patients with recurrent laryngeal chondrosarcomas do not have a poorer outcome after salvage total laryngectomy. The authors advocate partial laryngectomy if technically feasible.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0023-852X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
102
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
858-67
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1495350-Adult,
pubmed-meshheading:1495350-Aged,
pubmed-meshheading:1495350-Cell Transformation, Neoplastic,
pubmed-meshheading:1495350-Chondrosarcoma,
pubmed-meshheading:1495350-Female,
pubmed-meshheading:1495350-Follow-Up Studies,
pubmed-meshheading:1495350-Humans,
pubmed-meshheading:1495350-Laryngeal Cartilages,
pubmed-meshheading:1495350-Laryngeal Neoplasms,
pubmed-meshheading:1495350-Laryngectomy,
pubmed-meshheading:1495350-Lymphatic Metastasis,
pubmed-meshheading:1495350-Male,
pubmed-meshheading:1495350-Mesoderm,
pubmed-meshheading:1495350-Middle Aged,
pubmed-meshheading:1495350-S100 Proteins,
pubmed-meshheading:1495350-Treatment Outcome
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Laryngeal chondrosarcomas: a clinicopathologic study of 11 cases, including two "dedifferentiated" chondrosarcomas.
|
| pubmed:affiliation |
Department of Pathology, Mount Sinai School of Medicine of City University of New York, NY 10021.
|
| pubmed:publicationType |
Journal Article
|