Linked Life Data

1492864

Source:http://linkedlifedata.com/resource/pubmed/id/1492864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11A
pubmed:dateCreated
1993-3-2
pubmed:abstractText
The aim of this 3-month study was to assess the activity of dihydroergocristine (DHEC, CAS 17479-15-5) on organic brain syndrome. DHEC is an ergot alkaloid derivative with a dopaminergic activity on the central nervous system (CNS). It improves cerebral metabolism and increases the bioelectric potential in the cerebral cortex. The randomized double-blind trial versus placebo involved 240 outpatients (138 females and 102 males, mean age 68 years) recruited in 6 hospitals. Subjects with Hachinski Ischemic Score > 6 and Mini Mental State < 22 were excluded. Patients were randomly divided into 4 groups of 60 subjects each to receive either one 6-mg DHEC oral vial or placebo vial, or one 6-mg DHEC tablet or placebo tablet once daily for 3 months. Neuropsychological tests were performed at baseline, and then after 45 and 90 days of treatment. The statistical analysis of results showed a significant difference (p < 0.01) between DHEC and placebo groups with regard to the following tests: "Scale of Clinical Assessment for Geriatrics (SCAG), Digit Symbol, Digit Span, Toulouse-Pieron, Hamilton Depression Rating Scale and Rey's Words". The amelioration of clinical symptoms pointed out the equivalence of DHEC oral vials and tablets. The drug was well tolerated. It is concluded that DHEC is an effective and safe drug in the treatment or organic brain syndrome.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1410-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Dihydroergocristine in organic brain psychosyndrome. Multicenter placebo-controlled clinical double-blind study in 240 patients].
pubmed:affiliation
Abteilung Neurologie, San Paolo Hospital, Mailand, Italien.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial, Multicenter Study