Linked Life Data

1492744

Source:http://linkedlifedata.com/resource/pubmed/id/1492744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 4
pubmed:dateCreated
1993-2-26
pubmed:abstractText
The AD1 locus on chromosome 21 (MIM 104300) maps to the beta-amyloid precursor locus (APP) at approximately 27.7 Mb from pter (10.9 cM in males and 33.9 cM in females), flanked proximally by D21S8 and distally by D21S111, with D21S124 and D21S210 close but of uncertain order. AD1 accounts for 63 +/- 11% of multiplex Alzheimer pedigrees for which lod scores have been reported. Since a much smaller proportion of pedigrees have mutations in the cDNA for beta-amyloid (APP exons 16 and 17), it is likely that the AD1 locus spans controlling elements near those exons. There is no evidence for a second locus on chromosome 21. The remaining pedigrees may include sporadic cases as well as mutations at an AD2 locus on another chromosome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:geneSymbol
AD1, APP
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-301
pubmed:dateRevised
2006-8-9
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
The AD1 locus in familial Alzheimer disease.
pubmed:affiliation
Department of Child Health, University of Southampton, Princess Anne Hospital, UK.
pubmed:publicationType
Journal Article