Linked Life Data

1488946

Source:http://linkedlifedata.com/resource/pubmed/id/1488946

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-2-23
pubmed:abstractText
This experiment comprised 3 groups of calves, (+P2), (-P2) and (-P1), which all started their first grazing season as parasite-free calves. The (+P2)- and (-P2)-group grazed 2 seasons. In the first season the (-P2)-group of calves was grazing a pasture with no detectable trichostrongyles and treated with anthelmintics every second week. The untreated (+P2)-group grazed an Ostertagia ostertagi contaminated pasture. During the second grazing season these 2 original groups grazed together with a new group of first-year grazing calves (-P1) on paddocks infected with O. ostertagi. Parasitological analyses showed that (+P2)-group had negligible egg excretions in the second year in comparison with (-P2) and (-P1). This indicated, that the egg output may be regulated through acquired immunity. The difference in egg excretions was not reflected in the serum pepsinogen levels, which were only slightly elevated for all groups in the second year. Post mortem examination at the end of the experiment showed that only the (-P1)-group harboured relatively high numbers of worms in the abomasa at that time. Antibodies of 3 immunoglobulin classes were investigated: IgA, IgG1 and IgG2. The IgA and IgG1 responses correlated with the presence of developing and adult worms in the abomasa and they remained elevated in the (+P2)-group throughout the experiment, perhaps indicating an involvement of these antibodies in a protective immune response. In the (-P2)-group the IgA and IgG1 showed fast and sharp rises during the second season that most likely were age-related and as such a result of maturation of the immune system. The role of IgG2 is unclear as the IgG2 response was weak in all groups of calves and difficult to relate to the parasitological data.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-605X
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Development of immunity to Ostertagia ostertagi (Trichostrongylidae: Nematoda) in pastured young cattle.
pubmed:affiliation
Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't