Linked Life Data

1488108

Source:http://linkedlifedata.com/resource/pubmed/id/1488108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-2-23
pubmed:abstractText
Using single- and double-labelling immunocytochemistry with antibodies specific for the oestrogen receptor and calcitonin gene-related peptide (CGRP), we have demonstrated oestrogen receptor immunoreactivity in the sexually dimorphic CGRP-immunoreactive (IR) population of the medial preoptic area (MPOA). In the short-term gonadectomised female approximately 80% of preoptic CGRP-IR neurones were immunoreactive for the oestrogen receptor. In short-term gonadectomised males, a small population of CGRP-IR cells was visualised in the MPOA only after colchicine treatment. Approximately 30% of CGRP-IR cells in the male were oestrogen receptor-IR, accounting for 2% of the total population of cells containing oestrogen receptors in this area. In the colchicine-treated female, it is estimated that 10-15% of preoptic oestrogen receptor-IR cells contain CGRP. These results indicate that CGRP is synthesised by preoptic neurones with oestrogen receptors. Furthermore, the identification of oestrogen receptors in the sexually dimorphic CGRP population suggests that these neurones may be directly linked with gonadal steroid-dependent, sex-specific functioning of the MPOA.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
761-4
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Immunocytochemical identification of oestrogen receptors in preoptic neurones containing calcitonin gene-related peptide in the male and female rat.
pubmed:affiliation
Laboratoire de Neuroendocrinologie, Morphofonctionnelle, INSERM, CJF 91.10 Université de Bordeaux II, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't