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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1993-2-24
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pubmed:abstractText |
The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (non-selective) on PAF (50 ng kg-1; iv)-induced airway vascular leakage have been evaluated in guinea-pigs. Rolipram (3-300 micrograms kg-1; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10-1000 micrograms kg-1; iv) and theophylline (30 mg kg-1; iv) were without effects. The anti-leakage activity of rolipram may be of therapeutic value in asthma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0767-3981
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1487228-Animals,
pubmed-meshheading:1487228-Capillary Permeability,
pubmed-meshheading:1487228-Evans Blue,
pubmed-meshheading:1487228-Guinea Pigs,
pubmed-meshheading:1487228-Milrinone,
pubmed-meshheading:1487228-Phosphodiesterase Inhibitors,
pubmed-meshheading:1487228-Platelet Activating Factor,
pubmed-meshheading:1487228-Pyridones,
pubmed-meshheading:1487228-Pyrrolidinones,
pubmed-meshheading:1487228-Respiratory System,
pubmed-meshheading:1487228-Rolipram,
pubmed-meshheading:1487228-Theophylline
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pubmed:year |
1992
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pubmed:articleTitle |
Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: a comparison with milrinone and theophylline.
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pubmed:affiliation |
Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat València, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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