Linked Life Data

14872205

Source:http://linkedlifedata.com/resource/pubmed/id/14872205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-3-22
pubmed:abstractText
Converging evidence suggests a role for noradrenergic mechanisms in stress-induced reinstatement of cocaine seeking in animals. Yohimbine, an alpha(2)-adrenoceptor antagonist, is known to be anxiogenic and induce stress-related responses in humans and animals. Here, we tested the ability of yohimbine to reinstate cocaine-seeking behavior and induce behavioral and physiological signs characteristic of stress in squirrel monkeys. Monkeys were trained to self-administer cocaine under a second-order schedule of i.v. drug injection. Drug seeking subsequently was extinguished by substituting saline for cocaine injections and omitting the cocaine-paired stimulus. The ability of yohimbine and the structurally distinct alpha(2)-adrenoceptor antagonist RS-79948 to reinstate cocaine-seeking behavior was assessed by administering priming injections immediately before test sessions in which the cocaine-paired stimulus was either present or absent. Priming injections of yohimbine (0.1-0.56 mg/kg, i.m.) or RS-79948 (0.01-0.1 mg/kg, i.m.) induced dose-related reinstatement of cocaine-seeking behavior. The magnitude of yohimbine-induced reinstatement was similar regardless of the presence or absence of the cocaine-paired stimulus. Yohimbine also significantly increased salivary cortisol levels, a physiological marker of stress, as well as scratching and self-grooming, behavioral markers of stress in nonhuman primates. In drug interaction experiments, pretreatment with the alpha(2)-adrenoceptor agonist clonidine (0.1-0.3 mg/kg, i.m.) dose-dependently inhibited yohimbine-induced reinstatement of cocaine seeking. In contrast, pretreatment with the dopamine receptor antagonist flupenthixol failed to inhibit yohimbine-induced reinstatement of cocaine seeking. The results show that pharmacological blockade of alpha(2)-adrenoceptors can induce reinstatement of cocaine-seeking behavior and characteristic stress responses in squirrel monkeys, providing a potentially useful model of stress-induced relapse to drug seeking.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
686-93
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed-meshheading:14872205-Adrenergic alpha-Agonists, pubmed-meshheading:14872205-Adrenergic alpha-Antagonists, pubmed-meshheading:14872205-Analysis of Variance, pubmed-meshheading:14872205-Animals, pubmed-meshheading:14872205-Behavior, Addictive, pubmed-meshheading:14872205-Behavior, Animal, pubmed-meshheading:14872205-Clonidine, pubmed-meshheading:14872205-Cocaine-Related Disorders, pubmed-meshheading:14872205-Dopamine Antagonists, pubmed-meshheading:14872205-Dose-Response Relationship, Drug, pubmed-meshheading:14872205-Drug Interactions, pubmed-meshheading:14872205-Exploratory Behavior, pubmed-meshheading:14872205-Extinction, Psychological, pubmed-meshheading:14872205-Flupenthixol, pubmed-meshheading:14872205-Hydrocortisone, pubmed-meshheading:14872205-Motor Activity, pubmed-meshheading:14872205-Saimiri, pubmed-meshheading:14872205-Self Administration, pubmed-meshheading:14872205-Serine Endopeptidases, pubmed-meshheading:14872205-Time Factors, pubmed-meshheading:14872205-Vocalization, Animal, pubmed-meshheading:14872205-Yohimbine
pubmed:year
2004
pubmed:articleTitle
Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys.
pubmed:affiliation
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772-9102, USA. buyean_lee@hms.harvard.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.