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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-2-11
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pubmed:abstractText |
High-level expression of the telomerase reverse transcriptase (hTERT) in >85% of human cancers, in contrast with its restricted expression in normal adult tissues, points to hTERT as a broadly applicable molecular target for anticancer immunotherapy. CTLs recognize peptides derived from hTERT and kill hTERT+ tumor cells of multiple histologies in vitro. Moreover, because survival of hTERT+ tumor cells requires functionally active telomerase, hTERT mutation or loss as a means of escape may be incompatible with sustained tumor growth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AndersonKaren SKS,
pubmed-author:ChenDih-YihDY,
pubmed-author:DomchekSusan MSM,
pubmed-author:GeorgeDaniel JDJ,
pubmed-author:HahnWilliam CWC,
pubmed-author:HoarKara MKM,
pubmed-author:LodaMassimoM,
pubmed-author:MasutomiKenkichiK,
pubmed-author:NadlerLee MLM,
pubmed-author:SchultzeJoachim LJL,
pubmed-author:StephansKatherine FKF,
pubmed-author:VonderheideRobert HRH,
pubmed-author:XiaZhinanZ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
828-39
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14871958-Adult,
pubmed-meshheading:14871958-Aged,
pubmed-meshheading:14871958-Breast Neoplasms,
pubmed-meshheading:14871958-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14871958-Cancer Vaccines,
pubmed-meshheading:14871958-Cell Separation,
pubmed-meshheading:14871958-DNA-Binding Proteins,
pubmed-meshheading:14871958-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:14871958-Female,
pubmed-meshheading:14871958-Flow Cytometry,
pubmed-meshheading:14871958-HLA-A2 Antigen,
pubmed-meshheading:14871958-Hemocyanin,
pubmed-meshheading:14871958-Humans,
pubmed-meshheading:14871958-Immunoenzyme Techniques,
pubmed-meshheading:14871958-Major Histocompatibility Complex,
pubmed-meshheading:14871958-Male,
pubmed-meshheading:14871958-Middle Aged,
pubmed-meshheading:14871958-Mutation,
pubmed-meshheading:14871958-Neoplasms,
pubmed-meshheading:14871958-Peptides,
pubmed-meshheading:14871958-Phenotype,
pubmed-meshheading:14871958-Prostatic Neoplasms,
pubmed-meshheading:14871958-Telomerase,
pubmed-meshheading:14871958-Vaccines
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pubmed:year |
2004
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pubmed:articleTitle |
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
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pubmed:affiliation |
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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