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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-11
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pubmed:abstractText |
Patients with an acute myocardial infarction (AMI) are of high risk to develop ischemia-induced ventricular arrhythmias, leading to sudden cardiac death (SCD) in about one third of all AMI patients. The individual susceptibility to ischemia-induced arrhythmias may be modified by polymorphisms in genes encoding ion channels. The cardiac ATP-dependent potassium channel (K(ATP)) current is generated by ion channels encoded by the KCNJ11 gene and the SUR2a gene. Opening of the K(ATP) channel during ischemia results in action potential shortening in various studies and may therefore influence the outcome of AMI patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2828
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14871556-Aged,
pubmed-meshheading:14871556-Amino Acid Sequence,
pubmed-meshheading:14871556-Amino Acid Substitution,
pubmed-meshheading:14871556-Animals,
pubmed-meshheading:14871556-Blood Pressure,
pubmed-meshheading:14871556-Caenorhabditis elegans,
pubmed-meshheading:14871556-Conserved Sequence,
pubmed-meshheading:14871556-Death, Sudden, Cardiac,
pubmed-meshheading:14871556-Female,
pubmed-meshheading:14871556-Gene Frequency,
pubmed-meshheading:14871556-Haplotypes,
pubmed-meshheading:14871556-Humans,
pubmed-meshheading:14871556-Male,
pubmed-meshheading:14871556-Mice,
pubmed-meshheading:14871556-Middle Aged,
pubmed-meshheading:14871556-Molecular Sequence Data,
pubmed-meshheading:14871556-Myocardial Infarction,
pubmed-meshheading:14871556-Polymorphism, Genetic,
pubmed-meshheading:14871556-Polymorphism, Single Nucleotide,
pubmed-meshheading:14871556-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:14871556-Sequence Alignment
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pubmed:year |
2004
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pubmed:articleTitle |
KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction.
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pubmed:affiliation |
Klinik und Poliklinik für Innere Medizin II, Klinikum der Universität Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93042, Germany. andreas.jeron@klinik.uni-regensburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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