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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-2-11
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pubmed:abstractText |
The aim of this study was to investigate the synergism between neuropeptide Y and other vasoconstrictors (phenylephrine and serotonin) and which neuropeptide Y receptor subtype is responsible for the neuropeptide Y-induced potentiation. Exogenous neuropeptide Y (10 nM) potentiated alpha1-adrenoceptor-mediated (PE-induced) contraction in rat femoral artery permissively without its direct action, but not in the thoracic aorta. In contrast, neuropeptide Y produced no change in serotonin-induced contraction in both arteries. Increasing concentrations of neuropeptide Y caused dose-dependent potentiation of the phenylephrine-induced contraction in the femoral artery. This potentiation was blocked by a selective neuropeptide Y-Y1 receptor antagonist, BIBP3226 [(R)-N2-(diphenylacetyl)-N-[4-hydroxyphenyl)methyl]-argininamide] (1 microM). Semiquantitative reverse transcriptase polymerase chain reaction showed the selective expression of neuropeptide Y-Y1 receptor mRNA in the femoral artery. These findings indicated that the neuropeptide Y-induced selective potentiation of alpha1-adrenoceptor-mediated contraction is mediated through neuropeptide Y-Y1 receptor in rat femoral artery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/BIBP 3226,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y-Y1 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0160-2446
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S33-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14871026-Animals,
pubmed-meshheading:14871026-Aorta, Thoracic,
pubmed-meshheading:14871026-Arginine,
pubmed-meshheading:14871026-Dose-Response Relationship, Drug,
pubmed-meshheading:14871026-Drug Synergism,
pubmed-meshheading:14871026-Femoral Artery,
pubmed-meshheading:14871026-Gene Expression,
pubmed-meshheading:14871026-Humans,
pubmed-meshheading:14871026-Male,
pubmed-meshheading:14871026-Muscle, Smooth, Vascular,
pubmed-meshheading:14871026-Muscle Contraction,
pubmed-meshheading:14871026-Neuropeptide Y,
pubmed-meshheading:14871026-Phenylephrine,
pubmed-meshheading:14871026-Rats,
pubmed-meshheading:14871026-Rats, Wistar,
pubmed-meshheading:14871026-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:14871026-Receptors, Neuropeptide Y,
pubmed-meshheading:14871026-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14871026-Serotonin
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pubmed:year |
2003
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pubmed:articleTitle |
Neuropeptide Y selectively potentiates alpha1-adrenoceptor-mediated contraction through Y1 receptor subtype in rat femoral artery.
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pubmed:affiliation |
Division of Pharmacology, Department of Molecular Genetics and Signal Transduction Research, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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pubmed:publicationType |
Journal Article
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