|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1993-2-22
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|
pubmed:abstractText |
Thirty patients with first episode disciform keratitis and with no previous steroid exposure were randomly assigned to double blind treatment with 3% acyclovir ointment and 0.1% betamethasone (Betnesol) drops or acyclovir ointment and matching placebo. In the steroid group 14 of the 15 patients healed in a mean time of 21.8 days. In the placebo group eight of the 13 patients healed in a mean time of 34.5 days. The difference in mean healing time between the two groups was significant (p < 0.05). The cumulative rate of healing was also quicker in the steroid group when compared with the placebo group (p < 0.001). Other clinical parameters improved more favourably in the combination treatment group. Four patients, two in either group, experienced a mild transient punctate epitheliopathy, but no other serious adverse effects were noted. There has been no significant difference in the recurrence rate between the two groups after a mean follow-up period of approximately 3 years.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0007-1161
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
76
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
711-3
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|
pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1486070-Acyclovir,
pubmed-meshheading:1486070-Administration, Topical,
pubmed-meshheading:1486070-Adolescent,
pubmed-meshheading:1486070-Adult,
pubmed-meshheading:1486070-Aged,
pubmed-meshheading:1486070-Aged, 80 and over,
pubmed-meshheading:1486070-Betamethasone,
pubmed-meshheading:1486070-Child,
pubmed-meshheading:1486070-Double-Blind Method,
pubmed-meshheading:1486070-Drug Therapy, Combination,
pubmed-meshheading:1486070-Female,
pubmed-meshheading:1486070-Humans,
pubmed-meshheading:1486070-Keratitis,
pubmed-meshheading:1486070-Male,
pubmed-meshheading:1486070-Middle Aged,
pubmed-meshheading:1486070-Ophthalmic Solutions,
pubmed-meshheading:1486070-Time Factors,
pubmed-meshheading:1486070-Wound Healing
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|
pubmed:year |
1992
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|
pubmed:articleTitle |
Acyclovir ointment plus topical betamethasone or placebo in first episode disciform keratitis.
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|
pubmed:affiliation |
Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|
