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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1993-2-18
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pubmed:abstractText |
Streptomycin dose requirements were determined in an 83-year-old man with renal impairment who was being treated for miliary tuberculosis. Concentration measurements were interpreted using a Bayesian parameter estimation program. Estimated creatinine clearance (1.1 L/h) was used as a starting value for streptomycin clearance, and volume was initially assumed to be 0.3 L/kg. Bayesian estimates of clearance were close to the starting value and declined from 1.4 L/h to 0.9 L/h during the course of therapy. Volume was higher than the initial estimate (0.4-0.5 L/kg), possibly due to the patient having a low albumin and being underweight. Satisfactory concentrations were maintained for several weeks with doses of 500 mg every 36-48 h.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0163-4356
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
522-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading | |
pubmed:year |
1992
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pubmed:articleTitle |
Bayesian estimation of streptomycin pharmacokinetics.
|
pubmed:affiliation |
Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.
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pubmed:publicationType |
Journal Article,
Case Reports
|