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pubmed-article:1483736pubmed:abstractTextThis report describes the safety and efficacy of the procedure for percutaneous injection of medical-grade polyurethane elastomer (MPU) to form plugs in the vas deferens. The injection of 0.16-0.22 ml MPU in 53 men resulted in occlusion and azoospermia in 85% of the men after 12 months; 96% achieved azoospermia by 2 years. The success rate of the method and the rate of sperm suppression to azoospermia depended on the shapes of the plugs; this was determined by palpation after insertion. There were few complications and the results are discussed in terms of the reversibility potential of this method.lld:pubmed
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pubmed-article:1483736pubmed:authorpubmed-author:ChenZ WZWlld:pubmed
pubmed-article:1483736pubmed:authorpubmed-author:YinE JEJlld:pubmed
pubmed-article:1483736pubmed:authorpubmed-author:GoY SYSlld:pubmed
pubmed-article:1483736pubmed:authorpubmed-author:LiangX WXWlld:pubmed
pubmed-article:1483736pubmed:authorpubmed-author:Li-Honglld:pubmed
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pubmed-article:1483736pubmed:dateRevised2004-11-17lld:pubmed
pubmed-article:1483736pubmed:otherAbstractPIP: In China, physicians performed percutaneous injection of medical-grade polyurethane (MPU) in 53 men at the National Research Institute for Family Planning in Beijing and followed them for 2 years to evaluate the safety and efficacy of MPU vas occlusion. The injection of 1% procaine solution was used to kill residual spermatozoa in the distal reproductive tract. 1 year and within-subject fructose levels did not fluctuate greatly. 85% of the men reached azoospermia within 1 year after vas occlusion. 96% were azoospermic at 18 months. 2 men still had spermatozoa in the semen after 2 years (8-48 million ml-1). Both MPU plugs in most men (74%) had a regular shape. All of these men reached azoospermia by 18 months. 91% of the 11 men who had 1 regular and 1 irregular shaped MPU plug reached azoospermia by 18 months. This percentage fell to 67% for the 3 men whose MPU plugs were both irregular. The physicians had removed irregularly shaped MPU plugs in 5 men earlier and the elastomer filled the vas lumen and the surrounding vas surface. Recanalization did not occur in these 5 patients. 1 man with MPU vas occlusion developed a hematoma. 3 men experienced hemaspermia within 2 weeks after vas occlusion, but medication made it disappear within 4 weeks. Injection of 1% procaine solution may have damaged the seminal vesicles, resulting in the hemaspermia. Longterm complications did not occur.lld:pubmed
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pubmed-article:1483736pubmed:year1992lld:pubmed
pubmed-article:1483736pubmed:articleTitleSafety and efficacy of percutaneous injection of polyurethane elastomer (MPU) plugs for vas occlusion in man.lld:pubmed
pubmed-article:1483736pubmed:affiliationNational Research Institute for Family Planning, Beijing, China.lld:pubmed
pubmed-article:1483736pubmed:publicationTypeJournal Articlelld:pubmed