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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
26
|
| pubmed:dateCreated |
1993-2-8
|
| pubmed:abstractText |
A series of analogues of the antitumor alkaloids ellipticine and olivacine were tested for cytotoxicity against four human lung cancer cell lines: H69, N417, H460, and H358. Adriamycin (doxorubicin), ellipticine, olivacine, and celiptinium were used as standards. Adriamycin was cytotoxic at 2 microM and celiptinium was inactive at the highest concentrations tested (IC50 > 48 microM). N-methylcarbamates of 9-methoxy-6H-pyrido[4,3-b]carbazole 1-,5-, and 11-methanols gave IC50 values ranging from 0.02 to 0.11 microM against N417, H460, and H358 and were only slightly less effective against H69.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4854-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1479585-Animals,
pubmed-meshheading:1479585-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:1479585-Carbamates,
pubmed-meshheading:1479585-Ellipticines,
pubmed-meshheading:1479585-Humans,
pubmed-meshheading:1479585-Leukemia L1210,
pubmed-meshheading:1479585-Lung Neoplasms,
pubmed-meshheading:1479585-Mice,
pubmed-meshheading:1479585-Structure-Activity Relationship,
pubmed-meshheading:1479585-Tumor Cells, Cultured
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
N-methylcarbamate derivatives of ellipticine and olivacine with cytotoxic activity against four human lung cancer cell lines.
|
| pubmed:affiliation |
Cogswell Laboratory, Chemistry Department, Rensselaer Polytechnic Institute, Troy, New York 12180-3590.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|