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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1993-2-9
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pubmed:abstractText |
Distribution of metabolically 3H-labeled (1-->3)-beta-D-glucan (3H-SSG) obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395, in various tissues after intraperitoneal administration into ICR mice (250 micrograms/mouse) was examined. 3H-SSG was mainly detected in liver, spleen, and blood, and a negligible amount was excreted into the feces and excrement within 2 d. The significant amount of 3H-SSG remained in liver and spleen after 1 month. On the other hand, SSG was not incorporated effectively in vivo and in vitro by peritoneal exudate macrophages (0.5 microgram/1 x 10(6) M phi) Similarly in vivo, the majority of 3H-SSG distributed in spleen and liver were recovered from the non-cellular fraction and not from splenic macrophage and Kupffer cell fractions. These results suggested that (1-->3)-beta-D-glucans would not be easily incorporated by the host cells to degrade and exclude from the body even after the onset of the biological response modifier activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0386-846X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-26
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1479542-Animals,
pubmed-meshheading:1479542-Antineoplastic Agents,
pubmed-meshheading:1479542-Ascomycota,
pubmed-meshheading:1479542-Glucans,
pubmed-meshheading:1479542-Injections, Intraperitoneal,
pubmed-meshheading:1479542-Liver,
pubmed-meshheading:1479542-Macrophages,
pubmed-meshheading:1479542-Male,
pubmed-meshheading:1479542-Mice,
pubmed-meshheading:1479542-Mice, Inbred ICR,
pubmed-meshheading:1479542-Spleen,
pubmed-meshheading:1479542-Tissue Distribution,
pubmed-meshheading:1479542-beta-Glucans
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pubmed:year |
1992
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pubmed:articleTitle |
Tissue distribution of intraperitoneally administered (1-->3)-beta-D-glucan (SSG), a highly branched antitumor glucan, in mice.
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pubmed:affiliation |
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Japan.
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pubmed:publicationType |
Journal Article
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