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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1993-2-5
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pubmed:abstractText |
Previous studies on continuous hepatic artery infusions of recombinant interleukin-2 (IL-2) have shown that in a nontumor-bearing animal a continuous infusion given in a circadian "day cycled" pattern was much less toxic and could be given with 10 times higher doses of IL-2 than if the constant pattern of infusion was used. In the present study, circadian-patterned continuous hepatic artery infusions of IL-2 were used in hepatoma-bearing rats. Doses of 10 mg/m2/day could be tolerated when IL-2 was given in a "day cycle" rhythm. Control animals were given 1 mg/m2/day of constant infusion IL-2, which was the highest hepatic artery infusion dose tolerated at a constant rate without mortality in nontumor-bearing animals. Animals treated with the constant infusions of IL-2 had a 37.5% mortality rate and a 25% objective response rate in measurable tumor size. Animals receiving the "day cycle" had no mortality and a 100% objective response rate. The conclusion was that "day cycled" circadian-patterned continuous hepatic artery infusions of IL-2 could be given with much lower toxicity and much improved tumor response rates than constant continuous infusions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1053-8550
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-23
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pubmed:dateRevised |
2008-3-18
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pubmed:meshHeading |
pubmed-meshheading:1477073-Animals,
pubmed-meshheading:1477073-Circadian Rhythm,
pubmed-meshheading:1477073-Drug Administration Schedule,
pubmed-meshheading:1477073-Hepatic Artery,
pubmed-meshheading:1477073-Immunologic Factors,
pubmed-meshheading:1477073-Infusions, Intra-Arterial,
pubmed-meshheading:1477073-Interleukin-2,
pubmed-meshheading:1477073-Liver Neoplasms, Experimental,
pubmed-meshheading:1477073-Rats,
pubmed-meshheading:1477073-Rats, Sprague-Dawley,
pubmed-meshheading:1477073-Recombinant Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Improving responses in hepatomas with circadian-patterned hepatic artery infusions of recombinant interleukin-2.
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pubmed:affiliation |
Department of Surgery, St. Vincent's Hospital and Medical Center, New York, NY 10011.
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pubmed:publicationType |
Journal Article,
Comparative Study
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