Source:http://linkedlifedata.com/resource/pubmed/id/14770087
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-2-10
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| pubmed:abstractText |
Immunocompetent alloreactive donor lymphocytes directed against minor histocompatibility antigens are supposed to be responsible for graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) activity after allogeneic stem cell transplantation. The authors describe the detection of HA-1-specific T cells by peptide-loaded dimers and flow cytometry in the peripheral blood of a patient in complete remission but without GvHD after donor lymphocyte infusion for chemotherapy-resistant Philadelphia chromosome-positive acute lymphoblastic leukemia. The HA-1-specific T cells were sorted and an alloreactive, polyclonal T-cell line with specific lytic activity against HA-1-positive target cells, including leukemic cells, was established. Although P190 bcr/abl peptide-specific CD8positive T cells were detected in the peripheral blood at the same time, these T cells could not be expanded. Furthermore, no P190 bcr/abl peptide-specific T-cell response could be induced in vitro, even when peptide-loaded dendritic cells were used as stimulator cells. The authors conclude that in the absence of GvHD, HA-1-specific rather than P190 bcr/abl-specific T cells are responsible for ongoing GvL activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HA-1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A*02:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Minor Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1524-9557
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
156-60
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14770087-Cell Division,
pubmed-meshheading:14770087-Cell Lineage,
pubmed-meshheading:14770087-Cell Transplantation,
pubmed-meshheading:14770087-Dendritic Cells,
pubmed-meshheading:14770087-Dimerization,
pubmed-meshheading:14770087-Flow Cytometry,
pubmed-meshheading:14770087-Graft vs Leukemia Effect,
pubmed-meshheading:14770087-HLA-A Antigens,
pubmed-meshheading:14770087-HLA-A2 Antigen,
pubmed-meshheading:14770087-Hematopoietic Stem Cells,
pubmed-meshheading:14770087-Humans,
pubmed-meshheading:14770087-Immunotherapy,
pubmed-meshheading:14770087-Leukemia,
pubmed-meshheading:14770087-Lymphocytes,
pubmed-meshheading:14770087-Minor Histocompatibility Antigens,
pubmed-meshheading:14770087-Oligopeptides,
pubmed-meshheading:14770087-Peptides,
pubmed-meshheading:14770087-Phenotype,
pubmed-meshheading:14770087-Protein Binding,
pubmed-meshheading:14770087-T-Lymphocytes
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| pubmed:articleTitle |
Hematopoietic lineage-restricted minor histocompatibility antigen HA-1 in graft-versus-leukemia activity after donor lymphocyte infusion.
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| pubmed:affiliation |
Laboratory for Tumor and Immunobiology, Bone Marrow Transplant Unit, Division of Hematology & Oncology, Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria. brigitte.kircher@uklibk.ac.at
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| pubmed:publicationType |
Journal Article
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