Linked Life Data

14769545

Source:http://linkedlifedata.com/resource/pubmed/id/14769545

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-2-10
pubmed:abstractText
The aim of the present review is to summarize biological events in nasal epithelium after short-term exposure to diesel exhaust particles (DEP). Therefore human, animal, and in vitro studies carried out since 1987 are reviewed. Short-term exposure results included qualitative alterations characterized by immediate nasal hyperresponsiveness, antioxidant responses, marked epithelial inflammation, and a specific humoral response. In addition, studies on combined DEP/allergen challenge reported that, besides their intrinsic deleterious properties, DEP produced adjuvant-like effects on the immediate and late-phase response to allergen challenge, since they are able to mimic effects occurring after allergen challenge. DEP act deeply in nasal epithelium by (1) directing cytokine gene expression toward a Th2 profile, (2) enhancing local antigen-specific immunoglobulin E (IgE) production, and (3) driving in vivo isotype switch to IgE. Furthermore, DEP can induce in allergic subjects sensitization to a neoallergen, sensitization that did not occur with exposure to the neoantigen alone. Particulate pollutants such as DEP, encountered in urban areas, are therefore thought to be contributing causal factors to the exaggerated sensitization to allergens in subjects with appropriate genetic predisposition, sensitization that they might not otherwise have experienced. These findings add weight to the hypothesis that DEP are involved in the increased prevalence of airway allergic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-7404
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-104
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
A review of experimental studies on diesel exhaust particles and nasal epithelium alterations.
pubmed:affiliation
Laboratoire d'Hygiène et de Santé Publique, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France.
pubmed:publicationType
Journal Article, Review