Source:http://linkedlifedata.com/resource/pubmed/id/14767014
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-2-9
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| pubmed:abstractText |
The clinical course of IgA nephropathy is highly variable, ranging from complete remission to progression with end-stage renal disease. Although the mechanisms involved in disease progression are not characterized in detail, loss of renal function is positively correlated with mononuclear cell infiltration. In general, chemokines play an important role in the directional recruitment of inflammatory cells. Recently, a polymorphism in the distal 5' regulatory region of the chemokine monocyte chemoattractant protein-1 (MCP-1), which affects gene expression, has been described (A/G at position -2518). The aim of our study was to evaluate a possible association of this polymorphism with disease progression in patients with IgA nephropathy, as well as susceptibility to this form of glomerulonephritis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0931-0509
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
596-601
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14767014-Adolescent,
pubmed-meshheading:14767014-Adult,
pubmed-meshheading:14767014-Aged,
pubmed-meshheading:14767014-Aged, 80 and over,
pubmed-meshheading:14767014-Case-Control Studies,
pubmed-meshheading:14767014-Chemokine CCL2,
pubmed-meshheading:14767014-Child,
pubmed-meshheading:14767014-DNA,
pubmed-meshheading:14767014-European Continental Ancestry Group,
pubmed-meshheading:14767014-Female,
pubmed-meshheading:14767014-Genetic Predisposition to Disease,
pubmed-meshheading:14767014-Glomerulonephritis, IGA,
pubmed-meshheading:14767014-Humans,
pubmed-meshheading:14767014-Kidney Failure, Chronic,
pubmed-meshheading:14767014-Male,
pubmed-meshheading:14767014-Middle Aged,
pubmed-meshheading:14767014-Polymorphism, Genetic,
pubmed-meshheading:14767014-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:14767014-Retrospective Studies
|
| pubmed:year |
2004
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| pubmed:articleTitle |
No association of the -2518 MCP-1 A/G promoter polymorphism with incidence and clinical course of IgA nephropathy.
|
| pubmed:affiliation |
Medizinische Klinik IV, Universitätsklinikum Hamburg Eppendorf, Germany. o.steinmetz@uke.uni-hamburg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|