Source:http://linkedlifedata.com/resource/pubmed/id/14766435
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-2-9
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pubmed:abstractText |
There is a noticeable lack of targeted treatment options for marijuana dependence, in particular pharmacologic approaches. This is the first study evaluating a targeted pharmacologic approach for marijuana dependence. The goals of the study were to determine if such patients would seek pharmacologic treatment, whether these patients could be retained in treatment using a design previously developed for cocaine-dependent patients, and especially whether divalproex sodium showed promise as a treatment agent for marijuana dependence. We found that marijuana-dependent patients will seek treatment, and such patients can be adequately maintained in a pharmacologic trial. Regardless of treatment group, patients reported a significant reduction in their frequency and amount of marijuana use as well as a reduction in irritability. Given the lack of proven effective treatments for marijuana dependence, pharmacotherapies should be sought. The design of a preliminary clinical trial should include a psychosocial/behavioral intervention emphasizing motivation and medication compliance and a placebo control group.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/DA 09236,
http://linkedlifedata.com/resource/pubmed/grant/K02 DA 00288,
http://linkedlifedata.com/resource/pubmed/grant/K02 DA 00451,
http://linkedlifedata.com/resource/pubmed/grant/K02 DA 00465,
http://linkedlifedata.com/resource/pubmed/grant/K23 DA 00514
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1055-0496
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14766435-Administration, Oral,
pubmed-meshheading:14766435-Adult,
pubmed-meshheading:14766435-Cross-Over Studies,
pubmed-meshheading:14766435-Double-Blind Method,
pubmed-meshheading:14766435-Female,
pubmed-meshheading:14766435-GABA Agents,
pubmed-meshheading:14766435-Health Behavior,
pubmed-meshheading:14766435-Humans,
pubmed-meshheading:14766435-Irritable Mood,
pubmed-meshheading:14766435-Male,
pubmed-meshheading:14766435-Marijuana Abuse,
pubmed-meshheading:14766435-Patient Compliance,
pubmed-meshheading:14766435-Placebos,
pubmed-meshheading:14766435-Treatment Outcome,
pubmed-meshheading:14766435-Valproic Acid
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pubmed:articleTitle |
Pharmacotherapy for marijuana dependence: a double-blind, placebo-controlled pilot study of divalproex sodium.
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pubmed:affiliation |
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA. frl2@columbia.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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