GENERIC 14766125

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001675, umls-concept:C0023449, umls-concept:C0033325, umls-concept:C0231335, umls-concept:C0332147, umls-concept:C1254042
pubmed:issue	1
pubmed:dateCreated	2004-2-9
pubmed:abstractText	Acute lymphoblastic leukaemia (ALL) is a disease diagnosed in children as well as adults. Progress in the treatment of ALL has led to better survival rates, however, children have benefited more from improved treatment modalities than adults. Recent evidence has underscored that the difference in characteristics and biology of adult versus childhood ALL might be the result of a different origin. According to the two-hit paradigm of Knudson, to develop cancer two genetic events are necessary. It has been suggested, that in childhood ALL the first genetic event happens in the more mature lymphoid committed progenitor cells, whereas in adult ALL the first hit occurs in multipotent stem cells. This review compares patient characteristics, the extent of the disease, leukaemic cell characteristics and treatment between childhood and adult ALL. This is discussed in relation to the hypothesis that the maturation stage of the cells, from which the leukaemia arises, is responsible for the differential behaviour of adult and childhood ALL.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7502030
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0305-7372
pubmed:author	pubmed-author:KampsWillem AWA, pubmed-author:PlasschaertSabine L ASL, pubmed-author:VellengaEdoE, pubmed-author:de BontEveline S J MES, pubmed-author:de VriesElisabeth G EEG
pubmed:issnType	Print
pubmed:volume	30
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	37-51
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:14766125-Adolescent, pubmed-meshheading:14766125-Adult, pubmed-meshheading:14766125-Age Distribution, pubmed-meshheading:14766125-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:14766125-Biopsy, Needle, pubmed-meshheading:14766125-Child, pubmed-meshheading:14766125-Child, Preschool, pubmed-meshheading:14766125-Female, pubmed-meshheading:14766125-Humans, pubmed-meshheading:14766125-Immunohistochemistry, pubmed-meshheading:14766125-Male, pubmed-meshheading:14766125-Netherlands, pubmed-meshheading:14766125-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:14766125-Prevalence, pubmed-meshheading:14766125-Prognosis, pubmed-meshheading:14766125-Randomized Controlled Trials as Topic, pubmed-meshheading:14766125-Risk Factors, pubmed-meshheading:14766125-Sex Distribution, pubmed-meshheading:14766125-Survival Analysis
pubmed:year	2004
pubmed:articleTitle	Prognosis in childhood and adult acute lymphoblastic leukaemia: a question of maturation?
pubmed:affiliation	Department of Paediatric Haematology and Oncology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands.
pubmed:publicationType	Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't