Linked Life Data

1476553

Source:http://linkedlifedata.com/resource/pubmed/id/1476553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-2-11
pubmed:abstractText
An investigation was made into the characteristics of an experimental chronic alcoholic myopathy in the young rat. Male Wistar rats were fed a diet for 6 weeks in which ethanol comprised 36% of total energy. Controls were pair-fed the same diet except ethanol was substituted by isoenergic glucose. Soleus (type I fibre-rich) and plantaris (type II fibre-rich) muscles were examined by light microscopy, histochemistry and electron microscopy. Muscles from ethanol-fed rats showed a low-grade myopathy and the diameters of individual type II fibres were reduced. Infrequent atrophic fibres were necrotic and undergoing phagocytosis. Ultrastructurally, there were no observable differences in the subcellular organelles of the alcohol-fed and control rats. It was concluded that alcohol causes a specific myopathic process in the rat, selectively affecting type II fibres. These changes correlate well with the abnormalities seen in human chronic alcoholic myopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0735-0414
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-500
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Ethanol-induced chronic myopathy in the young rat: a light and electron microscopic study in type I or type II fibre-rich skeletal muscles.
pubmed:affiliation
Department of Histopathology, King's College School of Medicine and Dentistry, London, U.K.
pubmed:publicationType
Journal Article