Source:http://linkedlifedata.com/resource/pubmed/id/14764530
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-5-3
|
| pubmed:abstractText |
Donor alloreactive CD4(+) T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4(+) T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4(+) effector memory cells (CCR7(-)/CD62L(low), CD4(EM)). We analyzed CCR7 and CD62L expression on CD4(+) T cells from stem cell transplantation patients, who did or did not develop cGVHD, and healthy donors. Patients with cGVHD had a higher percentage of CD4(EM) cells (35.5% +/- 2.9%) than healthy donors (13.8% +/- 0.7%; P <.0001) or patients without cGVHD that received a transplant (21.7% +/- 2.1%; P <.01). Using corticosteroid dose as a surrogate marker for cGVHD severity, severe cGVHD was associated with a higher percentage of CD4(EM) cells. The proportion of CD4(EM) cells in corticosteroid-dependent patients with systemic lupus erythematosis or Wegener granulomatosis did not differ from patients without cGVHD that received a transplant. This finding implies that overrepresentation of CD4(EM) cells is a unique feature of cGVHD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0006-4971
|
| pubmed:author |
pubmed-author:BarrettA JohnAJ,
pubmed-author:BishopMichael RMR,
pubmed-author:CastroKathleenK,
pubmed-author:ChildsRichard WRW,
pubmed-author:ChoiUimookU,
pubmed-author:FosterSusan FSF,
pubmed-author:FowlerDaniel HDH,
pubmed-author:HakimFrancis TFT,
pubmed-author:HorwitzMitchell EME,
pubmed-author:IlleiGabor GGG,
pubmed-author:LeitmanSusan FSF,
pubmed-author:MalechHarry LHL,
pubmed-author:PavleticSteven ZSZ,
pubmed-author:SnellerMichael CMC,
pubmed-author:TamariMarisaM,
pubmed-author:WoltzPatricia CPC,
pubmed-author:YamashitaKouheiK
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3986-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14764530-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14764530-Case-Control Studies,
pubmed-meshheading:14764530-Chronic Disease,
pubmed-meshheading:14764530-Flow Cytometry,
pubmed-meshheading:14764530-Graft vs Host Disease,
pubmed-meshheading:14764530-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:14764530-Humans,
pubmed-meshheading:14764530-Immunologic Memory,
pubmed-meshheading:14764530-Immunophenotyping,
pubmed-meshheading:14764530-L-Selectin,
pubmed-meshheading:14764530-Receptors, CCR7,
pubmed-meshheading:14764530-Receptors, Chemokine,
pubmed-meshheading:14764530-T-Lymphocyte Subsets
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.
|
| pubmed:affiliation |
Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892-1886, USA. kyamashita@niaid.nih.gov
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|