Although hyperinsulinaemia in Type 2 diabetes in states of insulin resistance is a risk factor for atherosclerotic vascular disease, underlying mechanisms are poorly understood. We tested the hypothesis that insulin increases monocyte-endothelial interactions, which are implicated in atherosclerosis.
Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase.
Center of Excellence on Aging, Chair of Cardiology, G. d'Annunzio University-Chieti, Ospedale S. Camillo de Lellis, Via Forlanini, 50, 66100, Chieti, Italy.
