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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-2-5
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pubmed:abstractText |
The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-alpha promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-alpha gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA-DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls. Carriers of the TNF-alpha polymorphic -308 A allele were found to be more frequent in the pemphigus foliaceus group in comparison with the control group (odds ratio (OR) = 8.12; p = 0.0005). A significant association between HLA-DRB1*04 (OR = 3.86; pcor = 0.0001) and DRB1*14 (OR = 8.4; pcor = 0.0001) and pemphigus vulgaris was found. In this group of patients a decreased frequency of HLA-DRB1*07 (OR = 0.08; pcor = 0.006) was also identified. We have shown for the first time a positive association of TNF-alpha polymorphism in position -308 with pemphigus foliaceus.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-10417627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-10551416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-10620118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-10642599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-11704801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-11982641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-12233877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-12351419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-12496453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-1675792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-2217197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-2500728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-7871526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-8223882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-8426126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-8603520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-9027963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-9027971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-9096369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-9347787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-9459618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14760938-9802608
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0962-9351
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14760938-Female,
pubmed-meshheading:14760938-Gene Frequency,
pubmed-meshheading:14760938-Genotype,
pubmed-meshheading:14760938-HLA-DR Antigens,
pubmed-meshheading:14760938-HLA-DRB1 Chains,
pubmed-meshheading:14760938-Humans,
pubmed-meshheading:14760938-Male,
pubmed-meshheading:14760938-Middle Aged,
pubmed-meshheading:14760938-Pemphigus,
pubmed-meshheading:14760938-Polymorphism, Genetic,
pubmed-meshheading:14760938-Promoter Regions, Genetic,
pubmed-meshheading:14760938-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Tumour necrosis factor-alpha polymorphism as one of the complex inherited factors in pemphigus.
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pubmed:affiliation |
Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, 94-017 Lodz, Poland. torzecka@poczta.onet.pl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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