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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-4
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pubmed:abstractText |
Germ-line mutations in the BRCA1 tumor suppressor gene predispose to early onset breast cancers with a distinct phenotype characterized by high tumor grade, aneuploidy, high proliferation rate, and estrogen receptor-negativity. The molecular mechanisms and cooperative oncogenes contributing to multistep tumor progression in cells lacking BRCA1 are not well defined. To examine whether C-MYC (MYC), a transforming oncogene associated with genetic instability, contributes to multistep tumor progression in BRCA1-associated breast cancer, we have analyzed tumors from women with hereditary BRCA1-mutated and sporadic breast cancers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AdamsApril JAJ,
pubmed-author:AndersonKristin NKN,
pubmed-author:BlackwoodAnne MAM,
pubmed-author:DasSomaS,
pubmed-author:DignamJames JJJ,
pubmed-author:GrushkoTatyana ATA,
pubmed-author:HagosFitsum GFG,
pubmed-author:LynchHenry THT,
pubmed-author:OlopadeOlufunmilayo IOI,
pubmed-author:PerouCharles MCM,
pubmed-author:RidderstråleKarin KKK,
pubmed-author:SveenLiseL,
pubmed-author:WeberBarbara LBL,
pubmed-author:WeiMin-JieMJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
499-507
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14760071-Adult,
pubmed-meshheading:14760071-Alleles,
pubmed-meshheading:14760071-Breast Neoplasms,
pubmed-meshheading:14760071-Cell Division,
pubmed-meshheading:14760071-DNA Methylation,
pubmed-meshheading:14760071-Disease Progression,
pubmed-meshheading:14760071-Genes, BRCA1,
pubmed-meshheading:14760071-Genotype,
pubmed-meshheading:14760071-Germ-Line Mutation,
pubmed-meshheading:14760071-Humans,
pubmed-meshheading:14760071-In Situ Hybridization, Fluorescence,
pubmed-meshheading:14760071-Middle Aged,
pubmed-meshheading:14760071-Multivariate Analysis,
pubmed-meshheading:14760071-Mutation,
pubmed-meshheading:14760071-Phenotype,
pubmed-meshheading:14760071-Promoter Regions, Genetic,
pubmed-meshheading:14760071-Proto-Oncogene Proteins c-myc
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pubmed:year |
2004
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pubmed:articleTitle |
MYC is amplified in BRCA1-associated breast cancers.
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pubmed:affiliation |
Section of Hematology/Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, Chicago, Illinois 60637-1463, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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