Source:http://linkedlifedata.com/resource/pubmed/id/14759559
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2004-2-4
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pubmed:abstractText |
The receptor-linked internalization of [125I] human neuropeptide Y (NPY) in Chinese hamster ovary (CHO) cells expressing the guinea-pig Y1 receptors or in human endometrial carcinoma-1B (Hec-1B) cells expressing the human Y5 receptor, as well as the receptor-linked internalization of human pancreatic polypeptide (hPP) receptor expressed in CHO cells, is selectively inhibited by low molarities of the Li+ cation. The Na+ and K+ cations decreased the receptor-linked internalization of agonist peptides only at high molar inputs, and largely in proportion to the reduction of cell surface binding of Y ligand peptides, dependent on ion concentration and the type of Y receptor examined. With particulates isolated from disrupted cells, there was no preferential inhibition by Li+ relative to Na+ in the binding of type-specific ligand peptides to Y receptors of any type. The observed difference could be connected to the known ability of Li+ to modify active conformations of signal transducers, which may also directly or indirectly affect the internalization motors. The decrease in the rate of Y receptor internalization by Li+ also points to a possible alteration of Y receptor signaling in vivo by lithium at acute therapeutically employed dose levels.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Pancreatic Polypeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y-Y1 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y4 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y5 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0167-0115
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-74
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14759559-Animals,
pubmed-meshheading:14759559-Binding, Competitive,
pubmed-meshheading:14759559-CHO Cells,
pubmed-meshheading:14759559-Cricetinae,
pubmed-meshheading:14759559-Guinea Pigs,
pubmed-meshheading:14759559-Humans,
pubmed-meshheading:14759559-Ligands,
pubmed-meshheading:14759559-Lithium,
pubmed-meshheading:14759559-Neuropeptide Y,
pubmed-meshheading:14759559-Pancreatic Polypeptide,
pubmed-meshheading:14759559-Potassium,
pubmed-meshheading:14759559-Receptors, Neuropeptide Y,
pubmed-meshheading:14759559-Sodium
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pubmed:year |
2004
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pubmed:articleTitle |
Internalization of neuropeptide Y Y1 and Y5 and of pancreatic polypeptide Y4 receptors is inhibited by lithium in preference to sodium and potassium ions.
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pubmed:affiliation |
Department of Microbiology and Molecular Cell Sciences, University of Memphis, Memphis, TN 38152, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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