Linked Life Data

14759503

Source:http://linkedlifedata.com/resource/pubmed/id/14759503

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pubmed-article:14759503pubmed:abstractTextOral administration of the opioid antagonist nalmefene alone (up to 20 mg/kg) failed to show a significant effect on acute food intake in mice. However, combined oral dosing of nalmefene and subthreshold doses of AM251, a cannabinoid CB1 receptor inverse agonist, led to a significant reduction in food intake in both lean and diet-induced obese (DIO) mice. Furthermore, the anorectic effect of a high dose of AM251 was further enhanced when co-administered with nalmefene. The results support a synergistic interaction between opioid and cannabinoid systems in regulating feeding behavior.lld:pubmed
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pubmed-article:14759503pubmed:articleTitleSynergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice.lld:pubmed
pubmed-article:14759503pubmed:affiliationDepartment of Metabolic Disorders, PO Box 2000, RY80M-213, Rahway, NJ 07065, USA. richard_z_chen@merck.comlld:pubmed
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