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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-4
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pubmed:abstractText |
Oral administration of the opioid antagonist nalmefene alone (up to 20 mg/kg) failed to show a significant effect on acute food intake in mice. However, combined oral dosing of nalmefene and subthreshold doses of AM251, a cannabinoid CB1 receptor inverse agonist, led to a significant reduction in food intake in both lean and diet-induced obese (DIO) mice. Furthermore, the anorectic effect of a high dose of AM251 was further enhanced when co-administered with nalmefene. The results support a synergistic interaction between opioid and cannabinoid systems in regulating feeding behavior.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AM 251,
http://linkedlifedata.com/resource/pubmed/chemical/Cannabinoids,
http://linkedlifedata.com/resource/pubmed/chemical/Endocannabinoids,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Opioid Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/nalmefene
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
999
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-30
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pubmed:meshHeading |
pubmed-meshheading:14759503-Animals,
pubmed-meshheading:14759503-Appetite Regulation,
pubmed-meshheading:14759503-Body Weight,
pubmed-meshheading:14759503-Brain,
pubmed-meshheading:14759503-Cannabinoids,
pubmed-meshheading:14759503-Dose-Response Relationship, Drug,
pubmed-meshheading:14759503-Drug Synergism,
pubmed-meshheading:14759503-Endocannabinoids,
pubmed-meshheading:14759503-Homeostasis,
pubmed-meshheading:14759503-Male,
pubmed-meshheading:14759503-Mice,
pubmed-meshheading:14759503-Mice, Inbred C57BL,
pubmed-meshheading:14759503-Naltrexone,
pubmed-meshheading:14759503-Narcotic Antagonists,
pubmed-meshheading:14759503-Obesity,
pubmed-meshheading:14759503-Opioid Peptides,
pubmed-meshheading:14759503-Piperidines,
pubmed-meshheading:14759503-Pyrazoles,
pubmed-meshheading:14759503-Receptor, Cannabinoid, CB1
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pubmed:year |
2004
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pubmed:articleTitle |
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice.
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pubmed:affiliation |
Department of Metabolic Disorders, PO Box 2000, RY80M-213, Rahway, NJ 07065, USA. richard_z_chen@merck.com
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pubmed:publicationType |
Journal Article
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