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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-1
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pubmed:abstractText |
We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14758356-Adenoma,
pubmed-meshheading:14758356-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:14758356-Animals,
pubmed-meshheading:14758356-Cell Line, Tumor,
pubmed-meshheading:14758356-Dose-Response Relationship, Drug,
pubmed-meshheading:14758356-Genes, APC,
pubmed-meshheading:14758356-Humans,
pubmed-meshheading:14758356-Intestinal Neoplasms,
pubmed-meshheading:14758356-Intestinal Polyps,
pubmed-meshheading:14758356-Ligands,
pubmed-meshheading:14758356-Mice,
pubmed-meshheading:14758356-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:14758356-Thiazoles,
pubmed-meshheading:14758356-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth.
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pubmed:affiliation |
Department of Medicine, The Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6838, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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