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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-3
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pubmed:abstractText |
Tellimagrandin I is a hydrolysable tannin compound widely present in plants. In this study, the effect of tellimagrandin I on chemically induced erythroid and megakaryocytic differentiation was investigated using K562 cells as differentiation model. It was found that tellimagrandin I not only inhibited the hemoglobin synthesis in butyric acid (BA)- and hemin-induced K562 cells with IC50 of 3 and 40microM, respectively, but also inhibited other erythroid differentiation marker including acetylcholinesterase (AChE) and glycophorin A (GPA) in BA-induced K562 cells. Tellimagrandin I also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of CD61 protein, a megakaryocytic marker. RT-PCR analysis showed that tellimagrandin I decreased the expression of erythroid genes (gamma-globin and porphobilinogen deaminase (PBGD)) and related transcription factors (GATA-1 and NF-E2) in BA-induced K562 cells, whereas tellimagrandin I induced the overexpresison of GATA-2 transcription factor that played negative regulation on erythroid differentiation. These results indicated that tellimagrandin I had inhibitory effects on erythroid and megakaryocytic differentiation, which suggested that tannins like tellimagrandin I might influence the anti-tumor efficiency of some drugs and the hematopoiesis processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholinesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Benzidines,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Erythroid-Specific DNA-Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GATA2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gallic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosides,
http://linkedlifedata.com/resource/pubmed/chemical/Glycophorin,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylbilane Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/NF-E2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/NF-E2 Transcription Factor, p45...,
http://linkedlifedata.com/resource/pubmed/chemical/NFE2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/benzidine,
http://linkedlifedata.com/resource/pubmed/chemical/tellimagrandin I
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0378-4274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
147
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-19
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14757314-Acetylcholinesterase,
pubmed-meshheading:14757314-Benzidines,
pubmed-meshheading:14757314-Cell Differentiation,
pubmed-meshheading:14757314-Cholinesterase Inhibitors,
pubmed-meshheading:14757314-DNA Primers,
pubmed-meshheading:14757314-DNA-Binding Proteins,
pubmed-meshheading:14757314-Erythroid Precursor Cells,
pubmed-meshheading:14757314-Erythroid-Specific DNA-Binding Factors,
pubmed-meshheading:14757314-Flow Cytometry,
pubmed-meshheading:14757314-GATA1 Transcription Factor,
pubmed-meshheading:14757314-GATA2 Transcription Factor,
pubmed-meshheading:14757314-Gallic Acid,
pubmed-meshheading:14757314-Glucosides,
pubmed-meshheading:14757314-Glycophorin,
pubmed-meshheading:14757314-Hematopoiesis,
pubmed-meshheading:14757314-Hemoglobins,
pubmed-meshheading:14757314-Humans,
pubmed-meshheading:14757314-Hydroxymethylbilane Synthase,
pubmed-meshheading:14757314-K562 Cells,
pubmed-meshheading:14757314-Megakaryocytes,
pubmed-meshheading:14757314-NF-E2 Transcription Factor,
pubmed-meshheading:14757314-NF-E2 Transcription Factor, p45 Subunit,
pubmed-meshheading:14757314-RNA, Messenger,
pubmed-meshheading:14757314-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14757314-Tetradecanoylphorbol Acetate,
pubmed-meshheading:14757314-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Inhibitory effect of tellimagrandin I on chemically induced differentiation of human leukemia K562 cells.
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pubmed:affiliation |
Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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