Linked Life Data

14756081

Source:http://linkedlifedata.com/resource/pubmed/id/14756081

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-2-3
pubmed:abstractText
A possible precursor for invasive endometrial carcinoma is an in situ stage, but this notion is very much debated. We present a case of endometrial carcinoma diagnosed in a patient with post-menopausal bleeding. The morphological examination of the hysterectomy specimen, processed by routine technique, put in evidence focal atypias of the glandular epithelium in a group of few endometrial glands, on a background of atrophy without a desmoplastic stromal reaction. The immunohistochemical investigation of the steroid receptors and p53 protein, using monoclonal antibodies in the ABC technique, revealed the p53 positivity and the absence of the receptors in the focal malignant areas. The surface epithelium had the same immunohistochemical aspect. These aspects were decisive in precising that the malignant change was primarily in the surface epithelium with secondary extension in some glands, the final diagnosis being in situ serous papillary carcinoma.
pubmed:language
rum
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0048-7848
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
654-6
pubmed:dateRevised
2011-1-13
pubmed:meshHeading
pubmed:articleTitle
[Endometrial carcinoma in situ. Morphological and immunohistochemical aspects].
pubmed:affiliation
Disciplina de Morfopatologie, Facultatea de Medicin? Stomatologic?, Universitatea de Medicin? ?i Farmacie Gr.T. Popa Ia?i.
pubmed:publicationType
Journal Article, English Abstract, Case Reports