Linked Life Data

14754760

Source:http://linkedlifedata.com/resource/pubmed/id/14754760

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-5-26
pubmed:abstractText
To elucidate the apparent contradictions in vascular remodeling in the lungs of patients with idiopathic pulmonary fibrosis, we evaluated alveolar vascularity in relation to the various degrees of fibrosis in surgically biopsied lungs of usual interstitial pneumonia. Alveolar capillary endothelial cells were intensely immunoreactive with CD34 but not with von Willebrand factor. Vascular density, that is, the relative ratio of capillary area to total area of alveolar walls, was significantly higher at low grades of fibrosis than in control lungs, whereas vascular density gradually decreased as the degree of fibrosis increased and was lower than that of control lungs in the most extensively fibrotic lesions. No vessels were observed inside fibroblastic foci. The potent angiogenic factors vascular endothelial growth factor and interleukin-8 were abundantly produced by capillary endothelial cells and alveolar epithelial cells in highly vascularized alveolar walls. In contrast, venules with CD34-negative but von Willebrand factor-positive endothelial cells localized in the center of the fibrotic lesions were slightly increased and identified as postcapillary venules by three-dimensional reconstructed images. These results indicate the presence of heterogeneous vascular remodeling in usual interstitial pneumonia.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1203-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14754760-Antigens, CD34, pubmed-meshheading:14754760-Biological Markers, pubmed-meshheading:14754760-Capillaries, pubmed-meshheading:14754760-Endothelial Cells, pubmed-meshheading:14754760-Humans, pubmed-meshheading:14754760-Image Processing, Computer-Assisted, pubmed-meshheading:14754760-Imaging, Three-Dimensional, pubmed-meshheading:14754760-Immunohistochemistry, pubmed-meshheading:14754760-Interleukin-8, pubmed-meshheading:14754760-Ki-67 Antigen, pubmed-meshheading:14754760-Pulmonary Alveoli, pubmed-meshheading:14754760-Pulmonary Fibrosis, pubmed-meshheading:14754760-Pulmonary Veins, pubmed-meshheading:14754760-Severity of Illness Index, pubmed-meshheading:14754760-Statistics as Topic, pubmed-meshheading:14754760-Thrombomodulin, pubmed-meshheading:14754760-Vascular Endothelial Growth Factor A, pubmed-meshheading:14754760-von Willebrand Factor
pubmed:year
2004
pubmed:articleTitle
Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis.
pubmed:affiliation
Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. ebinam@idac.tohoku.ac.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Evaluation Studies