| pubmed-article:14749700 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C1335875 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C1705050 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C0037080 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:14749700 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:14749700 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14749700 | pubmed:dateCreated | 2004-2-24 | lld:pubmed |
| pubmed-article:14749700 | pubmed:abstractText | We previously reported the fusion of the TEL gene to the Syk gene in myelodysplastic syndrome with t(9;12)(q22;p12). TEL-Syk fusion transformed interleukin-3 (IL-3)-dependent murine hematopoietic cell line BaF3 to growth factor independence. Here, we investigate the intracellular signal transduction of the stable transfectants. TEL-Syk fusion protein was associated with the p85 subunit of phosphatidyl inositol 3 kinase (PI3-K) followed by the activation of Akt in the absence of IL-3. Vav, phospholipase C-gamma2 and mitogen-activated protein kinase (MAPK) were also constitutively activated. TEL-Syk also activated the signal transducer and activator of transcription 5 (STAT5) in the absence of Janus kinase 2 activation. None of these kinases were phosphorylated in the BaF3 cells transfected with TELDeltaPNT-Syk in which the oligomerization domain of TEL was deleted. Inhibitor analysis showed that the MAPK pathway was important in TEL-Syk-mediated cell proliferation. The immunofluorescence technique revealed that the TEL-Syk fusion protein was located in the cytoplasm. These data suggest that TEL-Syk fusion protein in the cytoplasm leads to the constitutive activation of PI3-K/Akt, MAPK and STAT5 signal pathways, which are closely involved in IL-3-independent cell proliferation of BaF3 cells. | lld:pubmed |
| pubmed-article:14749700 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14749700 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14749700 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14749700 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14749700 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:YamamotoTT | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:MatsudaTT | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:SaitoHH | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:AbeAA | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:NaoeTT | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:KunoYY | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:FONJJ | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:KanieTT | lld:pubmed |
| pubmed-article:14749700 | pubmed:author | pubmed-author:TowatariMM | lld:pubmed |
| pubmed-article:14749700 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14749700 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:14749700 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14749700 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14749700 | pubmed:pagination | 548-55 | lld:pubmed |
| pubmed-article:14749700 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:14749700 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14749700 | pubmed:articleTitle | TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways. | lld:pubmed |
| pubmed-article:14749700 | pubmed:affiliation | Department of Hematology, Graduate School of Medicine, Nagoya University, Nagoya, Japan. | lld:pubmed |
| pubmed-article:14749700 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14749700 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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