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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-29
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pubmed:abstractText |
Previous studies have indicated that in massive proteinuria, free fatty acids (FFAs) bound to albumin were overloaded in the proximal tubule and exacerbated tubulointerstitial damage. Liver-type fatty acid-binding protein (L-FABP) is an intracellular carrier protein of FFAs that is expressed in the proximal tubule of human kidney. We sought to evaluate urinary L-FABP as a clinical marker in chronic renal disease. Urinary L-FABP was measured in patients with nondiabetic chronic renal disease (n = 120) with the use of a newly established ELISA method. We then monitored these patients for 15 to 51 months. Clinical data were analyzed with multivariate analysis. Urinary L-FABP was correlated with urinary protein, urinary alpha(1)-microglobulin, and serum creatinine concentrations. Urinary L-FABP at the start of follow-up (F = 17.1, r =.36, P <.0001) was selected as a significant clinical factor correlated with the progression rate, defined as a slope of a reciprocal of serum creatinine over time. We next selected the patients with mild renal dysfunction (n = 35) from all 120 patients and divided them into 2 groups according to progression rate: the progression group (n = 22) and the nonprogression group (n = 13). Serum creatinine and urinary protein concentrations and blood pressure at the start of follow-up were higher in the progression group than in the nonprogression group, although we detected no significant difference between the 2 groups. Urinary L-FABP was significantly higher in the former group than in the latter (P <.05). The results showed that urinary L-FABP reflected the clinical prognosis of chronic renal disease. Urinary L-FABP may be a clinical marker that can help predict the progression of chronic glomerular disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/FABP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FABP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SPINT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitor, Kunitz Soybean,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2143
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
143
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-30
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:14749682-Animals,
pubmed-meshheading:14749682-Antibodies, Monoclonal,
pubmed-meshheading:14749682-Biological Markers,
pubmed-meshheading:14749682-Biopsy,
pubmed-meshheading:14749682-Carrier Proteins,
pubmed-meshheading:14749682-Creatinine,
pubmed-meshheading:14749682-Disease Progression,
pubmed-meshheading:14749682-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:14749682-Fatty Acid-Binding Proteins,
pubmed-meshheading:14749682-Female,
pubmed-meshheading:14749682-Follow-Up Studies,
pubmed-meshheading:14749682-Humans,
pubmed-meshheading:14749682-Kidney Failure, Chronic,
pubmed-meshheading:14749682-Liver,
pubmed-meshheading:14749682-Male,
pubmed-meshheading:14749682-Membrane Glycoproteins,
pubmed-meshheading:14749682-Mice,
pubmed-meshheading:14749682-Mice, Inbred BALB C,
pubmed-meshheading:14749682-Middle Aged,
pubmed-meshheading:14749682-Neoplasm Proteins,
pubmed-meshheading:14749682-Nerve Tissue Proteins,
pubmed-meshheading:14749682-Proteinuria,
pubmed-meshheading:14749682-Trypsin Inhibitor, Kunitz Soybean,
pubmed-meshheading:14749682-Tumor Suppressor Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease.
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pubmed:affiliation |
Second Department of Internal Medicine, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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