pubmed-article:14747283 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:14747283 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
pubmed-article:14747283 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:14747283 | lifeskim:mentions | umls-concept:C0030190 | lld:lifeskim |
pubmed-article:14747283 | lifeskim:mentions | umls-concept:C0021655 | lld:lifeskim |
pubmed-article:14747283 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
pubmed-article:14747283 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:14747283 | pubmed:dateCreated | 2004-1-28 | lld:pubmed |
pubmed-article:14747283 | pubmed:abstractText | Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only thrombosis and fibrosis but also to obesity and insulin resistance. Increased PAI-1 levels have been presumed to be consequent to obesity. We investigated the interrelationships of PAI-1, obesity, and insulin resistance in a high-fat/high-carbohydrate (HF) diet-induced obesity model in wild-type (WT) and PAI-1-deficient mice (PAI-1(-/-)). Obesity and insulin resistance developing in WT mice on an HF diet were completely prevented in mice lacking PAI-1. PAI-1(-/-) mice on an HF diet had increased resting metabolic rates and total energy expenditure compared with WT mice, along with a marked increase in uncoupling protein 3 mRNA expression in skeletal muscle, likely mechanisms contributing to the prevention of obesity. In addition, insulin sensitivity was enhanced significantly in PAI-1(-/-) mice on an HF diet, as shown by euglycemic-hyperinsulinemic clamp studies. Peroxisome proliferator-activated receptor (PPAR)-gamma and adiponectin mRNA, key control molecules in lipid metabolism and insulin sensitivity, were maintained in response to an HF diet in white adipose tissue in PAI-1(-/-) mice, contrasting with downregulation in WT mice. This maintenance of PPAR-gamma and adiponectin may also contribute to the observed maintenance of body weight and insulin sensitivity in PAI-1(-/-) mice. Treatment in WT mice on an HF diet with the angiotensin type 1 receptor antagonist to downregulate PAI-1 indeed inhibited PAI-1 increases and ameliorated diet-induced obesity, hyperglycemia, and hyperinsulinemia. PAI-1 deficiency also enhanced basal and insulin-stimulated glucose uptake in adipose cells in vitro. Our data suggest that PAI-1 may not merely increase in response to obesity and insulin resistance, but may have a direct causal role in obesity and insulin resistance. Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment. | lld:pubmed |
pubmed-article:14747283 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:language | eng | lld:pubmed |
pubmed-article:14747283 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14747283 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:14747283 | pubmed:month | Feb | lld:pubmed |
pubmed-article:14747283 | pubmed:issn | 0012-1797 | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:BrownNancy... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:VaughanDougla... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:McGuinnessOwe... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:FogoAgnes BAB | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:WassermanDavi... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:MaLi-JunLJ | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:SwiftLarry... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:TaylorKevin... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:KanjanabuchTa... | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:ZhangYaHuaY | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:GuanYouFeiY | lld:pubmed |
pubmed-article:14747283 | pubmed:author | pubmed-author:SteebW-HWH | lld:pubmed |
pubmed-article:14747283 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:14747283 | pubmed:volume | 53 | lld:pubmed |
pubmed-article:14747283 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:14747283 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:14747283 | pubmed:pagination | 336-46 | lld:pubmed |
pubmed-article:14747283 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:meshHeading | pubmed-meshheading:14747283... | lld:pubmed |
pubmed-article:14747283 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:14747283 | pubmed:articleTitle | Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. | lld:pubmed |
pubmed-article:14747283 | pubmed:affiliation | Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. | lld:pubmed |
pubmed-article:14747283 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:14747283 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:14747283 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:18787 | entrezgene:pubmed | pubmed-article:14747283 | lld:entrezgene |
entrez-gene:19016 | entrezgene:pubmed | pubmed-article:14747283 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14747283 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14747283 | lld:pubmed |