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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-1-27
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pubmed:abstractText |
Folic acid (FA) supplementation reduces neural tube defects (NTDs) by 70%. However, the cause of most NTDs cannot be attributed to folate deficiency, to mutations of genes that encode folate pathway enzymes, and folate receptors (FRs) that mediate cellular folate uptake. Mouse embryos nullizygous for the ortholog of the FRalpha gene have lethal congenital abnormalities that are preventable by administration of folinic acid to the dams. To determine whether antibodies to FRs are similarly teratogenic, we studied a rat model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Blocking,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Folate Receptors, GPI-Anchored,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Leucovorin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1542-0752
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
837-47
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14745937-Animals,
pubmed-meshheading:14745937-Antibodies, Blocking,
pubmed-meshheading:14745937-Antibody Specificity,
pubmed-meshheading:14745937-Autoantibodies,
pubmed-meshheading:14745937-Carrier Proteins,
pubmed-meshheading:14745937-Dexamethasone,
pubmed-meshheading:14745937-Disease Models, Animal,
pubmed-meshheading:14745937-Dose-Response Relationship, Immunologic,
pubmed-meshheading:14745937-Drug Therapy, Combination,
pubmed-meshheading:14745937-Embryonic and Fetal Development,
pubmed-meshheading:14745937-Female,
pubmed-meshheading:14745937-Folate Receptors, GPI-Anchored,
pubmed-meshheading:14745937-Folic Acid,
pubmed-meshheading:14745937-Injections, Intraperitoneal,
pubmed-meshheading:14745937-Leucovorin,
pubmed-meshheading:14745937-Pregnancy,
pubmed-meshheading:14745937-Rats,
pubmed-meshheading:14745937-Rats, Sprague-Dawley,
pubmed-meshheading:14745937-Receptors, Cell Surface
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pubmed:year |
2003
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pubmed:articleTitle |
Antibodies to folate receptors impair embryogenesis and fetal development in the rat.
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pubmed:affiliation |
SUNY-Downstate Medical Center, Department of Medicine, Brooklyn, New York 11203, USA. maria.dacosta@downstate.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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