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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0012634,
umls-concept:C0019704,
umls-concept:C0031437,
umls-concept:C0039194,
umls-concept:C0042776,
umls-concept:C0205191,
umls-concept:C0205329,
umls-concept:C0334094,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2587213,
umls-concept:C2911692
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2004-1-27
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|
pubmed:abstractText |
The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8+ T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Feb
|
|
pubmed:issn |
0022-1899
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
1
|
|
pubmed:volume |
189
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
515-9
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|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14745710-Anti-HIV Agents,
pubmed-meshheading:14745710-Antigens, CD95,
pubmed-meshheading:14745710-Biological Markers,
pubmed-meshheading:14745710-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14745710-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14745710-Chronic Disease,
pubmed-meshheading:14745710-Drug Therapy, Combination,
pubmed-meshheading:14745710-Female,
pubmed-meshheading:14745710-HIV Infections,
pubmed-meshheading:14745710-HIV Protease Inhibitors,
pubmed-meshheading:14745710-HIV-1,
pubmed-meshheading:14745710-Humans,
pubmed-meshheading:14745710-Lymphocyte Count,
pubmed-meshheading:14745710-Male,
pubmed-meshheading:14745710-Phenotype,
pubmed-meshheading:14745710-Prospective Studies,
pubmed-meshheading:14745710-T-Lymphocytes,
pubmed-meshheading:14745710-Viral Load
|
|
pubmed:year |
2004
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|
pubmed:articleTitle |
Association of T cell proliferative responses and phenotype with virus control in chronic progressive HIV-1 disease.
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|
pubmed:affiliation |
Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98109, USA. uma@u.washington.edu
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
