| pubmed-article:14742867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0022864 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0025265 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C1293097 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:14742867 | lifeskim:mentions | umls-concept:C1709019 | lld:lifeskim |
| pubmed-article:14742867 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14742867 | pubmed:dateCreated | 2004-2-5 | lld:pubmed |
| pubmed-article:14742867 | pubmed:abstractText | A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit. | lld:pubmed |
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| pubmed-article:14742867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14742867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742867 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14742867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14742867 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14742867 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14742867 | pubmed:author | pubmed-author:Goldman-Rakic... | lld:pubmed |
| pubmed-article:14742867 | pubmed:author | pubmed-author:Constantinidi... | lld:pubmed |
| pubmed-article:14742867 | pubmed:author | pubmed-author:TegnérJJ | lld:pubmed |
| pubmed-article:14742867 | pubmed:author | pubmed-author:WangX-JXJ | lld:pubmed |
| pubmed-article:14742867 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14742867 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:14742867 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:14742867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14742867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14742867 | pubmed:pagination | 1368-73 | lld:pubmed |
| pubmed-article:14742867 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14742867 | pubmed:meshHeading | pubmed-meshheading:14742867... | lld:pubmed |
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| pubmed-article:14742867 | pubmed:meshHeading | pubmed-meshheading:14742867... | lld:pubmed |
| pubmed-article:14742867 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14742867 | pubmed:articleTitle | Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. | lld:pubmed |
| pubmed-article:14742867 | pubmed:affiliation | Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA. xjwang@brandeis.edu | lld:pubmed |
| pubmed-article:14742867 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14742867 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14742867 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:14742867 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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