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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-2-5
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pubmed:abstractText |
A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-10441237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-10554991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-10594645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-10634775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-10982751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-11476885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-11524578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-11549620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-12461636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-12466463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-12601163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-12629166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-12907857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-14511514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-1691879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-2918358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-7643194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-7695894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-7731993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-8006226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-8113445,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14742867-9651498
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1368-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.
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pubmed:affiliation |
Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA. xjwang@brandeis.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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