| pubmed-article:14742501 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C0038411 | lld:lifeskim |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C0037278 | lld:lifeskim |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C1136170 | lld:lifeskim |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C1280477 | lld:lifeskim |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:14742501 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:14742501 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14742501 | pubmed:dateCreated | 2004-1-26 | lld:pubmed |
| pubmed-article:14742501 | pubmed:abstractText | Streptococcus pyogenes with null mutations in the csrRS regulatory locus are highly virulent in mice due to derepression of hyaluronic acid capsule synthesis and exotoxins, e.g., streptolysin S (SLS) and pyrogenic exotoxin B (SpeB). We generated derivatives of a DeltacsrRS strain that also carry deletions in hasAB (leading to an acapsular phenotype) or in sagA (phenotypically SLS-) or an interruption of speB (SpeB-) to test the relative contributions of these factors to the development of necrotic skin lesions. Inoculation of 2 x 10(6) to 4 x 10(6) CFU of either acapsular or SLS- strains into hairless mice resulted in lesions approximately 70% smaller than those of the DeltacsrRS parent strain. Elimination of SLS also reduced lethality from 100% to 0% at this inoculum (P < 10(-7); Fisher exact test). In contrast, SLS+ SpeB- mutants yielded lesions that were only 41% smaller than the parent strain (t = 2.2; P = 0.04), but only 3 the 17 lesions had dermal sloughing (P = 10(-5)). The nonulcerative lesions associated with SpeB- strains appeared pale with surrounding erythema. We conclude that capsule and SLS contribute to the subcutaneous spread of S. pyogenes and to a fatal outcome of infection. SpeB facilitates early dermal ulceration but has minor influence on lesion size and mortality. Large ulcerative lesions are observed only when both toxins are present. | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14742501 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14742501 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14742501 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14742501 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:14742501 | pubmed:author | pubmed-author:DiRitaVictor... | lld:pubmed |
| pubmed-article:14742501 | pubmed:author | pubmed-author:EnglebergN... | lld:pubmed |
| pubmed-article:14742501 | pubmed:author | pubmed-author:HeathAndrewA | lld:pubmed |
| pubmed-article:14742501 | pubmed:author | pubmed-author:VardamanKrist... | lld:pubmed |
| pubmed-article:14742501 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14742501 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:14742501 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14742501 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14742501 | pubmed:pagination | 623-8 | lld:pubmed |
| pubmed-article:14742501 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:meshHeading | pubmed-meshheading:14742501... | lld:pubmed |
| pubmed-article:14742501 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14742501 | pubmed:articleTitle | Contribution of CsrR-regulated virulence factors to the progress and outcome of murine skin infections by Streptococcus pyogenes. | lld:pubmed |
| pubmed-article:14742501 | pubmed:affiliation | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0378, USA. cengleb@umich.edu | lld:pubmed |
| pubmed-article:14742501 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14742501 | lld:pubmed |
