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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-1-26
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pubmed:abstractText |
A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-11000206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-11120945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-11257038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-11734627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-12213068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-2788277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-7692302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-7700387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-7745687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-8170948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-9094670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-9459011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-9525604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14742233-9641677
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.
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pubmed:affiliation |
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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