Linked Life Data

14741157

Source:http://linkedlifedata.com/resource/pubmed/id/14741157

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2004-1-26
pubmed:abstractText
Vaccines which offer better protection than BCG are now badly needed for controlling tuberculosis infection throughout the world. Immunological adjuvants capable of inducing a TH1 type of protective response are necessary to augment the immune response, particularly in the case of subunit vaccines. It is now well established that oligodeoxynucleotides (ODN) containing cytidine phosphate guanosine (CpG) motifs enhance cell-mediated responses in vivo by increasing the production of the TH1 cytokines IL-12 and interferon gamma (IFNgamma). To determine if this would improve subunit vaccination of mice CpG ODN were added to a subunit vaccine consisting of the culture filtrate proteins (CFP) of Mycobacterium tuberculosis H37Rv. It was observed that although adding CpG ODN to the vaccines promoted substantially increased IFNgamma production by lymph node cells draining sites of inoculation, this failed to translate after aerosol challenge into any degree of enhancement of bacterial clearance in the lungs, influx of IFN-positive T cells, or changes in histopathology. These data suggest that the vaccine enhancing effects of CpG ODN are relatively transient.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Incorporation of CpG oligodeoxynucleotide fails to enhance the protective efficacy of a subunit vaccine against Mycobacterium tuberculosis.
pubmed:affiliation
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Microbiology building, 1682 Campus Delivery, Fort Collins, CO 80523-1682, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't