Linked Life Data

1474064

Source:http://linkedlifedata.com/resource/pubmed/id/1474064

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-2-1
pubmed:abstractText
The alveolar epithelium is the major barrier to solute and protein flux between the pulmonary vascular bed and the airspaces. Hyperoxic exposure increases epithelial permeability, and during recovery, normal permeability must be regained. To determine the time course for recovery of this function, we exposed hamsters to > 95% O2 for 4.5 days and returned them to room air. After recovery periods of 0.5, 1, 3, 7, and 14 days, alveolar epithelial permeability x surface area (PS) values for [14C]sucrose and fluorescein isothiocyanate-Dextran 20 were measured with isolated perfused lung techniques. Eighty-five percent of the exposed animals survived in room air. Control PS values for sucrose and Dextran 20 were 5.76 x 10(-5) and 0.29 x 10(-5) cm3/s, respectively. After hyperoxia both values were increased by a factor of five. After 0.5 days of recovery, PS remained elevated, but after 1 day they were decreased. Normal PS values were achieved after 3 days for sucrose and 7 days for Dextran 20. During both acute injury and recovery, epithelial selectivity was unchanged and no ultrastructural changes in the alveolar epithelium were observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1881-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Time course of functional repair of the alveolar epithelium after hyperoxic injury.
pubmed:affiliation
Department of Pediatrics, University of Minnesota, Minneapolis 55455.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't