|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2004-1-26
|
|
pubmed:abstractText |
Growth failure is a leading problem in uncontrolled juvenile idiopathic arthritis. It also affects 10% of patients who are not treated with corticosteroids. The influence of proinflammatory cytokines like interleukin-1 beta, interleukin-6 and tumour necrosis factor on the neuroendocrine axis as well as on the production of insulin-like growth factors (IGFs) has been postulated. The objective of the current study was to evaluate effects of highly active antirheumatic treatment with tumour necrosis factor antagonist on growth retardation. Seven out of 18 patients with refractory juvenile idiopathic arthritis treated with etanercept demonstrated growth retardation leading to short stature.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0392-856X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
779-84
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:14740460-Adolescent,
pubmed-meshheading:14740460-Anthropometry,
pubmed-meshheading:14740460-Antirheumatic Agents,
pubmed-meshheading:14740460-Arthritis, Rheumatoid,
pubmed-meshheading:14740460-Body Height,
pubmed-meshheading:14740460-Child,
pubmed-meshheading:14740460-Dose-Response Relationship, Drug,
pubmed-meshheading:14740460-Drug Administration Schedule,
pubmed-meshheading:14740460-Female,
pubmed-meshheading:14740460-Follow-Up Studies,
pubmed-meshheading:14740460-Growth Disorders,
pubmed-meshheading:14740460-Humans,
pubmed-meshheading:14740460-Immunoglobulin G,
pubmed-meshheading:14740460-Injections, Subcutaneous,
pubmed-meshheading:14740460-Male,
pubmed-meshheading:14740460-Probability,
pubmed-meshheading:14740460-Prospective Studies,
pubmed-meshheading:14740460-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:14740460-Risk Assessment,
pubmed-meshheading:14740460-Sampling Studies,
pubmed-meshheading:14740460-Severity of Illness Index,
pubmed-meshheading:14740460-Statistics, Nonparametric
|
|
pubmed:articleTitle |
Growth reconstitution in juvenile idiopathic arthritis treated with etanercept.
|
|
pubmed:affiliation |
Department of Pediatrics, Martin-Luther University Halle-Wittenberg, Halle, Germany.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
